Background: Type 2 diabetes is a major health concern in México, particularly among women. According to national survey data, the prevalence of diabetes in 2018 for females was 18.7%  and 14.5% for males; these sex differences remained similar in 2020. Lack of proper self-care and disease management is a major underlying cause of death in diabetic patients. Existing research from cross-sectional studies suggests that gender roles and religiocultural beliefs impact self-care behaviors among Mexican women with type 2 diabetes, including self-exercise, self-monitoring of blood glucose, foot care, and dietary restrictions. Purpose: The purpose of this study is to explore how gender roles and religiocultural beliefs influence self-care behaviors among Mexican women with type 2 diabetes residing in two rural towns in San Luis Potosí, México. Methods: The proposed study will use a qualitative research approach to examine women’s self-care behaviors within a predominantly religious and cultural context. Semi-structured interviews will be conducted with 14 Mexican women with type 2 diabetes using the platica methodology. The platica is a Chicana/Latina feminist methodology described as a relational practice, and it is considered a culturally appropriate approach for connecting with Latina women. Proposed Findings: The proposed findings of this study aim to highlight how religion and culture influence self-care behaviors, contributing to a deeper understanding of the factors that shape the health practices and supporting the development of a culturally informed framework for diabetes self-care in areas deficient in self-care resources. Implications: Given the high prevalence of type 2 diabetes among Mexican women and the critical role of self-care in its management, it is necessary to identify patterns linking gender roles and religiocultural beliefs, as well as barriers and facilitators, to diabetes self-care.